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How do genetic and epigenetic changes

in the human genome lead to the specialization of human brain circuits 

01

Comparative multiomic characterization of the cortical subplate

02

Identifying genomic mechanisms underlying specialization of prefrontal cortex connectivity using in vivo epigenetic editing

03

Characterization of conserved and species-specific gene regulatory networks active in the developing prefrontal cortex

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What are the molecular mechanisms underlying the assembly of region-specific forebrain connectivity?​

01

single cell level characterization of subplate neuron function and connectivity using a novel mouse transgenic line

02

Spatiotemporal  characterization of non-clustered protocadherins in forebrain circuit assembly

03

Cell-intrinsic and extrinsic mechanisms involved in thalamic nuclei specification and connectivity

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01

Characterizing the effects of COVID-19 infection during pregnancy on brain development

02

Characterizing the longitudinal effects of risk alleles associated schizophrenia and autism spectrum on region specific connectome and transcriptome

03

Characterizing the effect of perinatal and early life stress on mouse models of psychiatric genetic risk alleles

How do genetic and environmental stressors during pregnancy disrupt the trajectory of forebrain development?

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