PATTABIRAMAN
NEURODEVELOPMENTAL
LABORATORY
How do genetic and epigenetic changes
in the human genome lead to the specialization of human brain circuits
01
Comparative multiomic characterization of the cortical subplate
02
Identifying genomic mechanisms underlying specialization of prefrontal cortex connectivity using in vivo epigenetic editing
03
Characterization of conserved and species-specific gene regulatory networks active in the developing prefrontal cortex
What are the molecular mechanisms underlying the assembly of region-specific forebrain connectivity?​​
01
single cell level characterization of subplate neuron function and connectivity using a novel mouse transgenic line
02
Spatiotemporal characterization of non-clustered protocadherins in forebrain circuit assembly
03
Cell-intrinsic and extrinsic mechanisms involved in thalamic nuclei specification and connectivity
01
Characterizing the effects of COVID-19 infection during pregnancy on brain development
02
Characterizing the longitudinal effects of risk alleles associated schizophrenia and autism spectrum on region specific connectome and transcriptome
03
Characterizing the effect of perinatal and early life stress on mouse models of psychiatric genetic risk alleles
How do genetic and environmental stressors during pregnancy disrupt the trajectory of forebrain development?